Investment Portfolio

A Non-Invasive Wearable Device That Alleviates Parkinson's Disease Symptoms

Assoc. Prof. Özgür Çakmak / Otago University, New Zealand


A wearable electro-stimulator that can alleviate Parkinson's Disease sysmptoms such as tremors, rigidity, and bradykinesia, etc. at the drug levels and without surgical intervention.

Today, patients are trying to alleviate their symptoms by taking many drugs. However, the drugs have several side effects such as involuntary movements, and mood swings. At further stages of the disease, patients may prefer to have a Deep Brain Stimulation operation. However, this operation requires an electrode to be placed in the relevant area of ​​the brain. In addition to that, a battery must be attached on to the patient's chest so that regular stimulation can be given to the patient. This operation is risky and costly so that it is not widely used.

The invention aimed to reduce drug dosages considerably and also be an alternative to Deep Brain Stimulation. It is also designed as an easy to use wearable device considering the patient comfort. The ultimate goal is to increase the life quality of millions of Parkinson's patients.

Clinical Trials

Various clinical trials have been conducted since 2013 and still continue. These are:

  • Short Term Effectiveness Clinical Trial
  • Animal Test Clinical Trial
  • Functional MRI Research Clinical Trial
  • Long Term Effect Clinical Trial
  • Long Term Effect International Clinical Trial


It is the second most common neuro degenerative disorder after Alzheimer. It affects more than 10mn people globally, in which 1.2 mn from Europe and 1 mn from USA. Regarding global treatment market size, it is expected to reach $5.69 billion by 2022 from $4.24 billion in  2017 at a CAGR of 6%.

Intellectual Property Rights

The first patent is granted in USA, Europe and Japan. In many countries, patent is pending. A second patent application were also filed to expand the scope of protection.

On June 2017, short term effectiveness clinical trial results published as an article on Frontiers in Human Neuroscience, which is a very high impact journal in neuroscience. The article title is "Rapid Alleviation of Parkinson’s Disease Symptoms via Electrostimulation of Intrinsic Auricular Muscle Zones." and you can reach from here.

Investment Status

A new prototype is developed and being tested in ongoing clinical trial. The incorporation process will be finished shorlty to advance international clinical trials and continue certification process. In the mean time additional R&D activities will continue. The goal is to provide the invention to the use of patients within 2 years.


Assoc. Prof. Özgür Çakmak

    • Senior Lecturer / Researcher, Otago University
    • Fellowship, Harvard Medical School,
    • Fellowship, Stanford University, School of Medicine
    • PhD., Marmara University, School of Medicine

Prof. Dr. Hakan Ürey

    • Professor, Koç University
    • PhD. Georgia Technology Institue, Electrical and Computer Engineering

Dr. Burak Özsoy

    • PhD., Texas Tech University, Mechanical Engineering